Endothelin 1

Mẫu hình biểu hiện RNA

Mẫu hình biểu hiện RNA

Thêm nguồn tham khảo về sự biểu hiện

Quá trình sinh học

UniProt


P05305

Bản thể genChức năng phân tửThành phần tế bàoQuá trình sinh học

Bản thể gen
Chức năng phân tử	• hormone activity • signaling receptor binding • cytokine activity • endothelin B receptor binding • GO:0001948 protein binding • endothelin A receptor binding
Thành phần tế bào	• Tế bào chất • Weibel-Palade body • basal part of cell • extracellular region • rough endoplasmic reticulum lumen • extracellular space • transport vesicle
Quá trình sinh học	• skeletal system development • response to amino acid • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • negative regulation of cellular protein metabolic process • positive regulation of MAP kinase activity • regulation of sensory perception of pain • Co mạch máu • body fluid secretion • positive regulation of sarcomere organization • positive regulation of cardiac muscle hypertrophy • cell surface receptor signaling pathway • cellular response to drug • multicellular organism aging • artery smooth muscle contraction • cellular response to interferon-gamma • positive regulation of chemokine-mediated signaling pathway • phosphatidylinositol 3-kinase signaling • response to leptin • positive regulation of mitotic nuclear division • cellular response to hypoxia • response to muscle stretch • cellular response to calcium ion • cellular response to transforming growth factor beta stimulus • positive regulation of renal sodium excretion • blood vessel morphogenesis • negative regulation of blood coagulation • response to nicotine • in utero embryonic development • neutrophil chemotaxis • heart development • positive regulation of prostaglandin secretion • vein smooth muscle contraction • cartilage development • rhythmic excitation • protein kinase C-activating G protein-coupled receptor signaling pathway • cellular response to glucocorticoid stimulus • branching involved in blood vessel morphogenesis • negative regulation of hormone secretion • positive regulation of smooth muscle contraction • negative regulation of nitric-oxide synthase biosynthetic process • positive regulation of prostaglandin-endoperoxide synthase activity • positive regulation of urine volume • positive regulation of JUN kinase activity • leukocyte activation • membrane depolarization • negative regulation of transcription by RNA polymerase II • response to ozone • respiratory gaseous exchange by respiratory system • positive regulation of heart rate • regulation of blood pressure • response to lipopolysaccharide • response to prostaglandin F • regulation of vasoconstriction • cellular response to interleukin-1 • response to salt • positive regulation of cell size • middle ear morphogenesis • sensory perception of pain • prostaglandin biosynthetic process • dorsal/ventral pattern formation • phospholipase D-activating G protein-coupled receptor signaling pathway • positive regulation of odontogenesis • regulation of pH • positive regulation of smooth muscle cell proliferation • protein kinase C deactivation • histamine secretion • maternal process involved in parturition • GO:0007243 intracellular signal transduction • response to hypoxia • neural crest cell development • regulation of systemic arterial blood pressure by endothelin • nitric oxide transport • positive regulation of cell migration • response to testosterone • positive regulation of cytosolic calcium ion concentration • epithelial fluid transport • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • cellular response to tumor necrosis factor • response to activity • response to dexamethasone • superoxide anion generation • positive regulation of endothelial cell migration • cellular response to peptide hormone stimulus • cellular response to fatty acid • peptide hormone secretion • cellular response to mineralocorticoid stimulus • positive regulation of cell population proliferation • inositol phosphate-mediated signaling • positive regulation of hormone secretion • negative regulation of smooth muscle cell apoptotic process • response to drug • calcium-mediated signaling • response to transforming growth factor beta • positive regulation of transcription by RNA polymerase II • positive regulation of DNA-binding transcription factor activity • positive regulation of cell growth involved in cardiac muscle cell development • positive regulation of neutrophil chemotaxis • regulation of signaling receptor activity • G protein-coupled receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • regulation of glucose transmembrane transport • negative regulation of gene expression • positive regulation of NIK/NF-kappaB signaling • positive regulation of vascular associated smooth muscle cell proliferation
Nguồn: Amigo / QuickGO

Kết thúc

12,297,194 bp [1]

Chức năng phân tử

• hormone activity
• signaling receptor binding
• cytokine activity
• endothelin B receptor binding
• GO:0001948 protein binding
• endothelin A receptor binding

Loài

Người

RefSeq (protein)


NP_001161791 NP_001946 NP_001161791 NP_001946

RefSeq (mRNA)


NM_001168319 NM_001955

Danh pháp

EDN1, ARCND3, ET1, HDLCQ7, QME, endothelin 1, PPET1

ID ngoài

HomoloGene: 1476 GeneCards: EDN1

PubMed

[2]

NST

Nhiễm sắc thể 6 (người)[1]

PDB

Tìm trên Human UniProt: PDBe RCSB

Thành phần tế bào

• Tế bào chất
• Weibel-Palade body
• basal part of cell
• extracellular region
• rough endoplasmic reticulum lumen
• extracellular space
• transport vesicle

Vị trí gen (Người)NSTBăngBắt đầuKết thúc

Vị trí gen (Người)

NST	Nhiễm sắc thể 6 (người)[1]

Băng	6p24.1	Bắt đầu	12,290,361 bp [1]
Kết thúc	12,297,194 bp [1]

Danh sách mã id PDB

Danh sách mã id PDB
1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH

BăngBắt đầu

6p24.1

Ensembl


ENSG00000078401

Vị trí gen (UCSC)

Chr 6: 12.29 – 12.3 Mb

Entrez


1906

Cấu trúc được biết đếnPDBDanh sách mã id PDB

Cấu trúc được biết đến

PDB

Tìm trên Human UniProt: PDBe RCSB

Danh sách mã id PDB
1EDN, 1EDP, 1T7H, 1V6R, 6DK5, 5GLH